Propyl Isothiocyanate → HCID 10845217, compound

Participants

Reaction Steps

The synthesis method of Example 1-(3) was applied. 3-Amino-1H-1,2,4-triazole (4.00 g), dimethylformamide (30 ml) and n-propyl isothiocyanate (5.7 ml) were used as reagents. After the reaction, the reaction mixture was purified by silica gel column chromatography (hexane-ethyl acetate) to give 3.07g of a 1:1 mixture of 5-amino-1-[n-propylamino(thiocarbonyl)]-1H-1,2,4-triazole and 3-amino-1-[n-propylamino(thiocarbonyl)]-1H-1,2,4-triazole as a white solid (yield 35%). The solid was applied to high performance liquid chromatography (acetonitrile-water) and recrystallization from hexane-ethyl acetate to give colorless transparent thin film crystals.

Provenance & Evidence