Methanol, 1,1-diethoxy-, 1-acetate → 2-Acetylamino-6-methyl-1,2,4-triazolo[1,5-a]-1,3,5-triazine-7(6H)-thione

HRID 1289797Notes

Reaction equation

HRID 1289797 reaction equation
[C:1]([NH:4][C:5]1[N:9]=[C:8]([NH2:10])[N:7]([C:11]([NH:13][CH3:14])=[S:12])[N:6]=1)(=[O:3])[CH3:2].[C:15](OC(OCC)OCC)(=O)C>>[C:1]([NH:4][C:5]1[N:9]=[C:8]2[N:10]=[CH:14][N:13]([CH3:15])[C:11](=[S:12])[N:7]2[N:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateHCID 18922226HCID 18922226, compound

Product 1

HCID 189222042-Acetylamino-6-methyl-1,2,4-triazolo[1,5-a]-1,3,5-triazine-7(6H)-thioneYield 87%

Procedure

The synthesis method of Example 55 was applied. The compound (1.02 g) obtained in Example 32 and diethoxymethyl acetate (10 ml) were used as reagents. The mixture was reacted at 100° C. for 5.5 hours to give 925 mg of white crystals (yield 87%).

Workup

  1. customThe synthesis method of Example 55
  2. customThe mixture was reacted at 100° C. for 5.5 hours

Sources & evidence

ORD record
ord-b68da1c1f70d4c80a710be83aa73fd56
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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