HCID 10773875, compound → HCID 10797921, compound

HRID 1289802Notes

Reaction equation

HRID 1289802 reaction equation
N[C:2]1[N:6]=[CH:5][N:4]([C:7]([NH:9][CH2:10][CH2:11][CH3:12])=[S:8])[N:3]=1.[NH2:13][C:14]1N(C(NCCC)=S)N=CN=1>C(OC(OCC)OCC)(=O)C>[CH2:10]([N:9]1[C:7](=[S:8])[N:4]2[N:3]=[CH:2][N:6]=[C:5]2[N:13]=[CH:14]1)[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 10773875HCID 10773875, compoundHCID 10845217HCID 10845217, compound2×

Product 1

HCID 10797921HCID 10797921, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateSolvent

Procedure

The synthesis method of Example 55 was applied. A 2:1 mixture (3.52 g) obtained in Example 47 of 5-amino-1-[n-propylamino(thiocarbonyl)]-1H-1,2,4-triazole and 3-amino-1-[n-propylamino(thiocarbonyl)]-1H-1,2,4-triazole and diethoxymethyl acetate (20 ml) were used as reagents. The mixture was reacted at 75° C. for 2 hours to give 2.22 g of white crystals (yield 95% from 5-amino-1-[n-propylamino(thiocarbonyl)]-1H-1-1,2,4-triazole), which were then subjected to recrystallization from water to give white crystals.

Workup

  1. customThe synthesis method of Example 55
  2. customThe mixture was reacted at 75° C. for 2 hours

Sources & evidence

ORD record
ord-8b673b4ae10540769d6580505f2a0314
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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