Fumaric Acid → HCID 69832285, compound

HRID 1289810Notes

Reaction equation

HRID 1289810 reaction equation
[CH3:1][C:2]([CH3:27])=[CH:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13](=[O:26])[C@:14]([CH:22]2[CH2:25][CH2:24][CH2:23]2)([OH:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:8][CH2:7]1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>C(O)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[CH3:1][C:2]([CH3:27])=[CH:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13](=[O:26])[C@:14]([CH:22]2[CH2:23][CH2:24][CH2:25]2)([OH:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 69831443HCID 69831443, compound

Product 1

HCID 69832285HCID 69832285, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

42 mg of (2R)-N-[1-(4-methyl-3-pentenyl)piperidin-4-yl]-2-cyclobutyl-2-hydroxy-2-phenylacetamide was dissolved in ethanol, and 13.2 mg of fumaric acid was added thereto. Recrystallization from hexane/ether gave 48 mg of the title compound.

Workup

  1. customRecrystallization from hexane/ether

Sources & evidence

ORD record
ord-5eb47df7bd2c4234aa71a45bbf803119
Source dataset
uspto-grants-1998_05
Patent number
US05750540

Reaction notes

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