HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Zolmitriptan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | (+/-)-3-(1-Methyl-4-piperidyl)-5-(2-oxo-1,3-oxazolidin-4-ylmethyl)-1H-indole | HCID 15233271 | — |
| Reactant | 5-[(4-Aminophenyl)methyl]-1,3-oxazolidin-2-one hydrochloride | HCID 70193604 | — |
| Reactant | (+/-)-N,N-Dimethyl-2-[5-(2-oxo-1,3-oxazolidin-5-ylmethyl)-1H-indol-3-yl]ethylamine hydrochloride | HCID 70195317 | — |
| Product | Zolmitriptan | HCID 60857 | — |
Reaction Steps
By steps identical to steps (d) to (f) of Synthetic Example 1 and Synthetic Example 2 or steps (d) and (e) of Synthetic Example 1 and Synthetic Example 3 and steps (e) to (h) of Synthetic Example 4, the product from step (a) was converted to (S)-N,N-dimethyl-2-[5-(2-oxo-l,3-oxazolidin-4-ylmethyl)-1H. indol-3-yl]ethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05466699 |
| Source dataset | uspto-grants-1995_11 |
| ORD ID | ord-39a76e6ff88b4521869994a8564a09f4 |
| Source note | uspto-grants-1995_11 |