反应详情

A mixture of 2,2-dimethylbutyrolactone (8.17 g, 71.7 mmol) and KOH (4.02 g,71.7 mmol) in 72 ml of water was refluxed overnight and then the mixture was concentrated in vacuo (50° C.). The crude residual oil was crystallized in ethanol/ether and the resulting white solid product was filtered and dried (100° C./0.1 mm) to afford 10.6 g (87%) of 4-hydroxy-2.2-dimethylbutyric acid monopotassium salt.

1. temperaturewas refluxed overnight
2. concentrationthe mixture was concentrated in vacuo (50° C.)
3. customThe crude residual oil was crystallized in ethanol/ether
4. filtrationthe resulting white solid product was filtered
5. customdried (100° C./0.1 mm)