3-(Trifluoromethyl)benzylamine → HCID 18922799, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure for example 1-step 2 except that 3-ethoxy-4-(tert-butylamino)-cyclobut-3-ene-1,2-dione was used in place of (R)-3-ethoxy-4-(1,2,2-trimethyl-propylamino)-cyclobut-3-ene-1,2-dione and 3-trifluoromethyl-benzylamine was used in place of 4-fluoro-benzylamine. Yield: 73%; mp: 237-239° C.; 1H NMR (300 MHz, DMSO-d6) δ 1.36 (s, 9H), 4.81-4.87 (m, 2H), 7.57 (s, 1H), 7.60-7.77 (m, 4H), 7.82 (brm, 1H); IR (KBr, cm-1): 3233m, 3059w, 2973w, 1793w, 1653s, 1571s, 1540s, 1471m, 1447m, 1354m, 1166m, 1127m; MS (CI) m/z (relative intensity): 327 (M+ +H, 80); Anal. Calcd. for C16H17 F3N2O2 : C, 58.89; H, 5.25; N, 8.58. Found: C, 58.99; H, 5.23; N, 8.47.

Provenance & Evidence