1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(S)-phenyl-3-(R)-(((S)-(2-pyrrolidon-5-yl))-methylamino)cyclopentane → 1-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-phenyl-3-(S)-(aminocarbonylmethylamino)cyclopentane

Participants

Reaction Steps

##STR10## 1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(S)-phenyl-3-(R)-(aminocarbonylmethylamino)cyclopentane; ##STR11## methyl 3-(R)-((4-methoxyphenyl)methylamino)-2-(R)-(4-fluorophenyl)cyclopentane-1-(R)-carboxylate; ##STR12## methyl 3-(S)-((4-methoxyphenyl)methylamino)-2-(R)-(4-fluorophenyl)cyclopentane-1-(R)-carboxylate; ##STR13## methyl 3-(S)-((4-methoxyphenyl)methylamino)-2-(S)-(4-fluorophenyl)cyclopentane-1-(S)-carboxylate; ##STR14## methyl 3-(R)-((4-methoxyphenyl)methylamino)-2-(S)-(4-fluorophenyl)cyclopentane-1-(S)-carboxylate; ##STR15## methyl 3-(S)-((2-methoxy-5-(1-tetrazolyl)phenyl)methylamino)-2-(R)-(4-fluorophenyl)cyclopentane-1-(R)-carboxylate; ##STR16## methyl 3-(S)-((2-methoxy-5-(1-tetrazolyl)phenyl)methylamino)-2-(S)-(4-fluorophenyl)cyclopentane-1-(S)-carboxylate; ##STR17## methyl 3-(S)-((3,5-bis(trifluoromethyl)phenyl)carbonylamino)-2-(R)-(4-fluorophenyl)cyclopentane-1-(R)-carboxylate; ##STR18## methyl 3-(S)-(N-((3,5-bis(trifluoromethyl)phenyl)carbonyl)-N-methylamino)-2-(R)-(4-fluorophenyl)cyclopentane-1-(R)-carboxylate; ##STR19## methyl 3-(S)-(1-(RS)-(3,5-bis(trifluoromethyl)phenyl)ethylamino)-2-(R)-(4-fluorophenyl)cyclopentane-1-(R)-carboxylate; ##STR20## 1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(S)-phenyl-3-(R)-(((S)-(2-pyrrolidon-5-yl))-methylamino)cyclopentane; ##STR21## 1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(S)-phenyl-3-(R)-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylamino)cyclopentane;

Provenance & Evidence