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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1289952Generated: October 30, 2026

Iodoacetamide → 1-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-phenyl-3-(S)-(aminocarbonylmethylamino)cyclopentane

https://huagongshe.com/reaction/1289952

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIodoacetamideHCID 3727—
Reactant1-(r)-(1-(s)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-2-(r)-phenyl-3-(s)-aminocyclopentaneHCID 22885634—
Product1-(R)-(1-(S)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-phenyl-3-(S)-(aminocarbonylmethylamino)cyclopentaneHCID 22885633—

Reaction Steps

The title compound was prepared using the amine from Example 27 and iodoacetamide using essentially the same procedure as Example 10. Mass spec (NH3 /CI): 475 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05750549
Source datasetuspto-grants-1998_05
ORD IDord-35f99bf39a1547248fb2c0c2a30c5778
Source noteuspto-grants-1998_05