Ammonium Chloride → HCID 178505750, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 342 mg of product from Step D in 7 mL of DMF was added 215 mg of sodium azide and 176 mg of ammonium chloride. The reaction was heated at 125° C. for 4 days and then cooled and diluted with water and extracted twice with ether. The organic layers were washed with a portion of brine, combined, dried over sodium sulfate and evaporated. The residue was purified by flash chromatography with 5% methanol in methylene chloride to obtain 250 mg of title compound as a oil. T.l.c. (5% methanol in methylene chloride) Rf =0.2. Mass spec (NH3 /CI): 353(M+1).

Provenance & Evidence