Hydrochloric Acid → HCID 15225718, compound

Participants

Reaction Steps

A suspension of 1.5 g (0.0047 mol) of 6,9-dimethyl-2-phenyl-9H-imidazo[1,2-a]benzimidazole-3-acetic acid is prepared in 50 ml of dry tetrahydrofuran, 1.22 g (0.0075 mol) of N,N'-carbonyldiimidazole are added thereto and the mixture is stirred for 2 h. The solution obtained is treated with an excess of dry gaseous methylamine and stirred for several hours. The solvent is evaporated under reduced pressure. The residue is taken up in water and the solid residue is isolated by filtration. After drying, the product is purified by silica gel column chromatography, eluting with a dichloromethane/methanol 95/5 mixture. The product obtained is then treated with a hydrochloric acid solution. The precipitate is collected by filtration and treated with an excess of ammonium hydroxide up to a pH of 9 to 10. A solid is isolated which is washed with water and dried. 0.79 g of product is obtained. Melting point: 251°-253° C.

Provenance & Evidence