HCID 10822693, compound → HCID 67668804, compound

HRID 1289981Notes

Reaction equation

HRID 1289981 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([N:10]=[N+]=[N-])[CH:6]1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:4].[CH3:20][O:21][C:22]1[CH:29]=[CH:28][C:27]([C:30]2[CH:34]=[CH:33][S:32][CH:31]=2)=[CH:26][C:23]=1[CH:24]=O>>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:24][C:23]2[CH:26]=[C:27]([C:30]3[CH:34]=[CH:33][S:32][CH:31]=3)[CH:28]=[CH:29][C:22]=2[O:21][CH3:20])[CH:6]1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:4]

Participants

3

Reactant 2

HCID 10822693HCID 10822693, compoundHCID 18922366HCID 18922366, compound

Product 1

HCID 67668804HCID 67668804, compound

Procedure

The title compound was prepared by employing the method described in Example 91, Step D with (1RS,2RS,3RS)-2-(4-fluorophenyl)-3-azidocyclopentanecarboxylic acid methyl ester (from Example 89, Step A) and the known 2-methoxy-5-(thiophen-3-yl)benzaldehyde (P. J. Ward, D. R. Armour, D. E. Bays, B. Evans, G. M. P. Giblin, N. Hernon, T. Hubbard, K. Liang, D. Middlemiss, J. Mordaunt, A. Naylor, N. A. Pegg, M. V. Vinder, S. P. Watson, C. Bountra, and D. C. Evans, J. Med. Chem. 1995, 38, 4985-92).

Sources & evidence

ORD record
ord-91a0e8d652934ebc81d8f11edbd14886
Source dataset
uspto-grants-1998_05
Patent number
US05750549

Reaction notes

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