2-methoxy-5-(5-pyrimidinyl)Benzaldehyde → HCID 67668087, compound

Participants

Reaction Steps

The title compound was prepared by employing the method described in Example 91, Step D with (1RS,2RS,3RS)-2-(4-fluorophenyl)-3-azidocyclopentanecarboxylic acid methyl ester (from Ex. 89, Step A) and the known 2-methoxy-5-(pyrimidin-5-yl)benzaldehyde (P. J. Ward, et al., J. Med. Chem. 1995, 38, 4985-92). 1H NMR (400 MHz, CD3OD): δ 9.07 (s, 1H), 8.99 (s, 2H), 7.61 (dd, 1H, J=9,2 Hz), 7.45 (d, 1H, J=2 Hz), 7.22 (dd, 2H, J=9,5 Hz), 7.07 (t, 2H, J=9 Hz), 7.02 (d, 1H, J=9 Hz), 3.76 (d, 1H, J=13 Hz), 3.59 (s, 3H), 3.56 (s, 3H), 3.55-3.49 (m, 1H), 3.53 (d, 1H, J=13 Hz), 3.45-3.36 (m, 1H), 3.26 (td, 1H, J=6,2 Hz), 2.36-2.26 (m, 1H), 2.12-2.01 (m, 1H), 1.99-1.88 (m, 2H). Mass spectrum (NH3 /CI): 436 (M+1).

Provenance & Evidence