HCID 10560828, compound → HCID 67666854, compound

HRID 1289986Notes

Reaction equation

HRID 1289986 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([N:10]=[N+]=[N-])[CH:6]1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:4].[CH3:20][O:21][C:22]1[CH:29]=[CH:28][C:27]([C:30]2[S:31][CH:32]=[CH:33][N:34]=2)=[CH:26][C:23]=1[CH:24]=O>>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:24][C:23]2[CH:26]=[C:27]([C:30]3[S:31][CH:32]=[CH:33][N:34]=3)[CH:28]=[CH:29][C:22]=2[O:21][CH3:20])[CH:6]1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:4]

Participants

3

Reactant 2

HCID 10560828HCID 10560828, compoundHCID 18922366HCID 18922366, compound

Product 1

HCID 67666854HCID 67666854, compound

Procedure

The title compound was prepared by employing the method described in Example 91, Step D with (1RS,2RS,3RS)-2-(4-fluorophenyl)-3-azidocyclopentanecarboxylic acid methyl ester (from Example 89, Step A) and the known 2-methoxy-5-(thiazol-2-yl)benzaldehyde (P. J. Ward, et al., J. Med. Chem. 1995, 38, 4985-92).

Sources & evidence

ORD record
ord-eee23f7838b948aa80dec3a3078d1dd7
Source dataset
uspto-grants-1998_05
Patent number
US05750549

Reaction notes

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