HCID 10728207, compound → HCID 67668612, compound

HRID 1289996Notes

Reaction equation

HRID 1289996 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([N:10]=[N+]=[N-])[CH:6]1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:4].[CH3:20][C:21]1[C:25]([C:26]2[CH:27]=[CH:28][C:29]([O:34][CH3:35])=[C:30]([CH:33]=2)[CH:31]=O)=[C:24]([CH3:36])[O:23][N:22]=1>>[CH3:1][O:2][C:3]([CH:5]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:31][C:30]2[CH:33]=[C:26]([C:25]3[C:21]([CH3:20])=[N:22][O:23][C:24]=3[CH3:36])[CH:27]=[CH:28][C:29]=2[O:34][CH3:35])[CH:6]1[C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:4]

Participants

3

Reactant 2

HCID 10728207HCID 10728207, compoundHCID 18922366HCID 18922366, compound

Product 1

HCID 67668612HCID 67668612, compound

Procedure

The title compound was prepared by employing the method described in Example 91, Step D with (1RS,2RS,3RS)-2-(4-fluorophenyl)-3-azidocyclopentanecarboxylic acid methyl ester (from Example 89, Step A) and the known 5-(3,5-dimethylisoxazol-4-yl)-2-methoxybenzaldehyde (P. J. Ward, et al., J. Med. Chem. 1995, 38, 4985-92).

Sources & evidence

ORD record
ord-2f221c96c7324d218a0822672d0ce4b5
Source dataset
uspto-grants-1998_05
Patent number
US05750549

Reaction notes

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