HCID 18922481, compound → HCID 18922526, compound

Participants

Reaction Steps

To a solution of ethyl 4-methoxy-2-(4-pyridyl)-thiazole-5-carboxylate (169 mg, 0.639 mmol) in THF (4 mL) cooled in an ice-bath was added lithium aluminum hydride portionwise (48 mg, 1.26 mmol). After stirring for 15 minutes at ice temperature, excess LAH was destroyed by sequential addition of water (48 μL), 15% aqueous NaOH (48 μL), and water (144 μL). The mixture was diluted with THF, filtered through a pad of Celite, and evaporated. The title compound was purified by flash chromatography eluting with 25% acetone/hexane.

Provenance & Evidence