Methyl morpholine oxide → HCID 18922480, compound

Participants

Reaction Steps

5-(Hydroxymethyl)-4-methoxy-2-(4-pyridyl)-thiazole (182 mg, 0.777 mmol) was dissolved in methylene chloride (4 mL) and treated with 4-methylmorpholine-N-oxide (135 mg, 1.15 mmol), powdered 4A molecular sieves (385 mg), and tetrapropylammonium perruthenate (TPAP) (14 mg, 0.040 mmol) overnight at room temperature. The mixture was applied to a column of silica gel and eluted with 25% acetone in hexane to afford 62 mg of title compound.

Provenance & Evidence