Methylamine → HCID 19373114, compound

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Reaction Steps

Under a nitrogen stream, a suspension of 1.0 g (0.0028 mol) of 2-(4-chlorophenyl)-6,9-dimethyl-9H-imidazo[1,2-a]benzimidazole-3-acetic acid is prepared in 50 ml of dry tetrahydrofuran. 1.0 g (0.0063 mol) of N,N'-carbonyldiimidazole in solution in 50 ml of dry tetrahydrofuran is added and the mixture is stirred for 6 h. The solution is then treated with an excess of dry gaseous methylamine and again stirred for 4 h. The solvent is evaporated under reduced pressure. The residue is taken up in water, drained, washed with water and dried. 0.65 g of product is obtained which is purified by silica gel column chromatography, eluting with a chloroform/acetone 93/7 mixture. 0.26 g of compound is finally isolated. Melting point: 258°-260° C.

Provenance & Evidence