Potassium Hydroxide → HCID 15895301, compound

HRID 1290059Notes

Reaction equation

HRID 1290059 reaction equation
[OH-].[K+].[CH2:3]([C:6]1([CH2:22][CH2:23][CH3:24])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16]#[C:17][Si](C)(C)C)[CH:14]=2)[S:9][CH2:8][CH2:7]1)[CH2:4][CH3:5]>O.C(O)C>[CH2:22]([C:6]1([CH2:3][CH2:4][CH3:5])[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:16]#[CH:17])[CH:14]=2)[S:9][CH2:8][CH2:7]1)[CH2:23][CH3:24]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 15540938HCID 15540938, compound2×

Product 1

HCID 15895301HCID 15895301, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 1.82 g (32.4 mmol) of potassium hydroxide in 1.8 mL of water and 10.0 mL of ethanol was added to 1.22 g (3.70 mmol) of (4,4-dipropylthiochroman-6-yl)(trimethylsilyl)acetylene (Compound 30) and the resulting mixture stirred at room temperature for 5 hours during which time it became homogeneous. The solvent was removed in-vacuo and the residue was acidified with 5% aq H2SO4 and the product was extracted with 2×50 mL of ether.

Workup

  1. customThe solvent was removed in-vacuo
  2. extractionthe product was extracted with 2×50 mL of ether

Sources & evidence

ORD record
ord-b0ca947c20704d12b3e6404792946f3f
Source dataset
uspto-grants-1998_05
Patent number
US05750693

Reaction notes

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