2-Methoxyethylamine → HCID 19373124, compound

Participants

Reaction Steps

A suspension of 3.5 g (0.11 mol) of 9-methyl-2-(4-methylphenyl)-9H-imidazo[1,2-a]benzimidazole-3-acetic acid is prepared in 70 ml of dry tetrahydrofuran, 2.67 g (0.165 mol) of N,N'-carbonyldiimidazole are added in small portions, over 10 min, and the mixture is stirred at room temperature for 1 h. It is cooled in an ice-cold water bath, and 1.65 g (0.165 mol) of 2-methoxyethylamine in solution in 4 ml of dry tetrahydrofuran are added. Stirring is continued for 1 h at cold temperature, and then at room temperature for 4 h. The solvent is evaporated under reduced pressure. The residue is crystallized from water. The solid is collected by filtration, washed, dried and recrystallized from ethanol. 2.9 g of compound are finally obtained. Melting point: 189°-190° C.

Provenance & Evidence