Ammonia → HCID 22101782, compound

HRID 1290141Notes

Reaction equation

HRID 1290141 reaction equation
[NH3:1].[Cl:2][C:3]1[C:4](F)=[N:5][C:6]([F:13])=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1>C(O)C>[NH2:1][C:4]1[C:3]([Cl:2])=[CH:8][C:7]([C:9]([F:12])([F:11])[F:10])=[C:6]([F:13])[N:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 11042190HCID 11042190, compound

Product 1

HCID 22101782HCID 22101782, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
55 °C

Procedure

12.5.g (0.74 mol) of gaseous ammonia were passed into a stirred mixture of 40 g (0.184 mol) of 3-chloro-2,6-difluoro-5-trifluoromethylpyridine in 200 ml of ethanol in the course of 45 minutes at 50°-60 C. After the reaction mixture had been stirred for 11/2 hours at 55° C., it was cooled and concentrated. The residue was stirred in water, filtered off with suction and dried, giving 36.7 g (93% of theory) of the title compound of m.p. 101°-103° C.

Workup

  1. temperatureit was cooled
  2. concentrationconcentrated
  3. stirringThe residue was stirred in water
  4. filtrationfiltered off with suction
  5. customdried

Sources & evidence

ORD record
ord-dd21ea42029e440e87b8243742cd983f
Source dataset
uspto-grants-1998_05
Patent number
US05750705

Reaction notes

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