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2-Methoxynaphthalene → Methyl 2-hydroxy-2-(6-methoxynaphthalen-2-yl)propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methoxynaphthalene | HCID 7119 | — |
| 反応物 | Methyl pyruvate | HCID 11748 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 2-hydroxy-2-(6-methoxynaphthalen-2-yl)propanoate | HCID 11043497 | 52% |
反応手順
A mixture of 2-methoxynaphthalene (20,0 g, 126 mmol) and methyl pyruvate (19,3 g, 190 mmol) in dichloromethane (100 mL) was added to a suspension of aluminium chloride (25,3 g, 190 mmol) in dichloromethane (100 mL) at 6° C. over 140 minutes. The solution was stirred for a further 15 minutes at this temperature and added to ice/water. Methyl 2-hydroxy-2-(6-methoxynaphth-2-yl)propionate (52% yield) and 2-methoxynaphthalene (34% recovery) were the primary components of the reaction mixture.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05750764 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-02447c5588774be8b7233e763d628dc0 |
| 出典メモ | uspto-grants-1998_05 |