2-Methoxynaphthalene → HCID 67674172, compound

Participants

Reaction Conditions

Reaction Steps

Aluminium chloride (162 g, 12,2 mmol) was added in 3 portions to a solution of 2-methoxynaphthalene (1,28 g, 8,09 mmol) in nitromethane (20 mL) at 5° C. Ethyl pyruvate (1,41 g, 12,2 mmol) in nitromethane (10 mL) was added over 1 hour at this temperature. The reaction was allowed to proceed for 1 hour and warmed to 20° C. for 2 hours. Ethyl 2-hydroxy-2-(6-methoxynaphth-6-yl)propionate was formed with a selectivity of 16% at 52% conversion of the starting material.

Provenance & Evidence