反应详情

A mixture of freshly fused KHSO4 (2,50 g, 18 mmol), ethyl 2-hydroxy-2-(6-methoxynaphth-2-yl)propionate (0,60 g, 2,19 mmol), butylated hydroxytoluene (0,007 g) and toluene was refluxed for 22 hours. The mixture was filtered hot and the residue was washed with hot dichloromethane (3×30 ml). The solvent was removed and the crude oil was submitted to flash chromatography on silica gel, giving ethyl 2-(6-methoxynaphth-2-yl)acrylate (0,088 g, 16%) as a white solid.

1. temperaturewas refluxed for 22 hours
2. filtrationThe mixture was filtered hot
3. washthe residue was washed with hot dichloromethane (3×30 ml)
4. customThe solvent was removed