Pyridine → HCID 11195461, compound

HRID 1290316Notes

Reaction equation

HRID 1290316 reaction equation
[NH:1]([C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])[C@H:2]([C:4](O)=[O:5])[CH3:3].N1C(F)=NC(F)=NC=1[F:19].N1C=CC=CC=1>C(Cl)Cl>[NH:1]([C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8])[C@H:2]([C:4]([F:19])=[O:5])[CH3:3]

Participants

5

Reactant 3

HCID 1049PyridineHCID 12664Cyanuric fluorideHCID 736104N-carbobenzyloxyalanine

Product 1

HCID 11195461HCID 11195461, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

CBZ-Ala (1 mmole) in dry CH2Cl2 is kept under nitrogen and treated with cyanuric fluoride (8 mmol) and pyridine (1 mmole) to form the corresponding CBZ-Ala-F.

Sources & evidence

ORD record
ord-3f7d042d082f4ea2a2af1ce27f90b1c8
Source dataset
uspto-grants-1998_05
Patent number
US05750767

Reaction notes

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