HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nabumetone → 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nabumetone | HCID 4409 | — |
| Reactant | 1-(5-Bromo-6-methoxynaphthalen-2-yl)ethan-1-one | HCID 622178 | — |
| Product | 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one | HCID 70179405 | — |
Reaction Steps
New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750793 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-37bfe041c442425998114372078aa3dc |
| Source note | uspto-grants-1998_05 |