反应详情

温度

0 °C

To a 0° C. solution, under argon, of 0.821 g of product from Example 56 and 3.4 ml of pyridine is added 148 microliter of methanesulfonyl chloride. The reaction is stirred at 0° C. for 2 hours, diluted with water and extracted with chloroform. The organic layer washed with water and saturated sodium chloride, dried and concentrated in vacuo. The residue is purified by chromatography (Silica Gel; 80% ethyl acetate/hexane) to give 0.632 g of the desired product.

1. extractionextracted with chloroform
2. washThe organic layer washed with water and saturated sodium chloride
3. customdried
4. concentrationconcentrated in vacuo
5. customThe residue is purified by chromatography (Silica Gel; 80% ethyl acetate/hexane)