HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trisodium Phosphate → 3-[[5-(Aminomethyl)tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trisodium Phosphate | HCID 24243 | — |
| Reactant | 3-[[5-(Azidomethyl)tetrahydro-3-furanyl]thio]-6-(1-Hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester | HCID 86750323 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-[[5-(Aminomethyl)tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | HCID 74971528 | 51.5% |
Reaction Steps
The title compound is prepared by the procedure of Example 18 using 0.320 g of product from Example 63, 0.220 g of 10% palladium/carbon, 12 ml of 0.05M sodium phosphate buffer (pH 7) and 32 ml of dioxane to give 0.112 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750735 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-4482b934aa584332bf67072a099a8253 |
| Source note | uspto-grants-1998_05 |