反应详情

A 0° C. solution, under argon, of 0.279 g of product from Example 141 in 3 ml of dry methyl alcohol is treated with 0.35 ml of 4.35M sodium methoxide. After 2 hours, the reaction mixture is concentrated in vacuo and the residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane) to give 0.0465 g of the desired product.

1. concentrationthe reaction mixture is concentrated in vacuo
2. customthe residue purified by chromatography (silica gel: 0-5% diethyl ether/hexane)