HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 5-(2,4-Difluorophenyl)tetrahydro-3-furanthiol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Isopropanol hydrochloride | HCID 21912024 | — |
| Reactant | Sodium methanolate methanol | HCID 23694274 | — |
| Reactant | (+/-)-Ethanethioic acid S-[5-(2,4-difluorophenyl)tetrahydro-3-furanyl]ester | HCID 85719043 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | 5-(2,4-Difluorophenyl)tetrahydro-3-furanthiol | HCID 18923990 | 86% |
Reaction Steps
The title compound is prepared by the procedure of Example 16 using 0.250 g of product from Example 166, 243 μl of 25% sodium methoxide/methyl alcohol, 4.5 ml of tetrahydrofuran and 530 μl of 2N hydrochloric acid/isopropyl alcohol to give, after chromatography (silica gel: 5-10% ethyl acetate/hexane), 0.180 g of the desired product, as a mixture of isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05750735 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-489358265b594cae8ab612555f8db3df |
| Source note | uspto-grants-1998_05 |