反应详情

To a solution of 2.83 g of product from Example 255 in 43 ml of dioxane is added 1.28 g of N-hydroxysuccinimide and 2.30 g of 1,3-dicyclohexylcarbodiimide, hereinafter called DCC, in 13 ml of dioxane. The formed suspension is stirred at room temperature overnight. The urea by-product is collected and the filtrate is concentrated in vacuo to give an oil. The oil is dissolved in methylene chloride, washed with water, the layers are separated and the organic phase is cooled. The formed crystals are collected and dried to give 1.87 g of the desired product.

1. customThe urea by-product is collected
2. concentrationthe filtrate is concentrated in vacuo
3. customto give an oil
4. washwashed with water
5. customthe layers are separated
6. temperaturethe organic phase is cooled
7. customThe formed crystals are collected
8. customdried