Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 4-Isopropyl-6-(benzyloxycarbonylmethoxy)-2-phenylthiomethylsaccharin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Isopropyl-6-hydroxy-2-phenylthiomethylsaccharin | HCID 10316654 | — |
| 반응물 | Benzylbromoacetate | HCID 21881508 | — |
| 생성물 | 4-Isopropyl-6-(benzyloxycarbonylmethoxy)-2-phenylthiomethylsaccharin | HCID 69959543 | — |
반응 단계
A mixture of 4-isopropyl-6-hydroxy-2-phenylthiomethyl-saccharin (3.5 g, 9.63 mmol), acetone (25 mL) and K2CO3 (2.66 g, 19.26 mmol) was stirred under nitrogen for 2 minutes, then benzylbromoacetate (2.4 mL, 14.45 mmol) was added. The mixture was stirred for 6 hours, filtered, and the filtrate was concentrated in vacuo. The residue was purified by medium pressure chromatography eluting with 20% ethyl acetate/hexane to afford 4.67 (100%) of 4-isopropyl-6-(benzyloxycarbonylmethoxy)-2-phenylthiomethylsaccharin.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05466701 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-e9f3eb7da128481f975bd89182c9bd1c |
| 출처 메모 | uspto-grants-1995_11 |