Trifluoroacetic acid → Trifluoroacetate

Participants

Reaction Steps

Boc-L-Asp(OBzl)-L-Phe-OBzl (9.91 g) was dissolved in a mixture of trifluoroacetic acid (50 ml) and dichloromethanie (50 ml). The resultant solution was stored at room temperature for 2 hr. The reaction mixture was evaporated to dryness to yield a residue which was triturated with ether, collected, washed thoroughly with ether and dried under high vacuum to yield L-Asp(OBzl)-L-Phe-OBzl, trifluoroacetate salt (8.36 g) as a white solid: NMR (CDCl3) δ 2.88(2H,m), 3.07(2H,m), 4.33(1H,m), 4.78(1H,m), 5.02(2H,s), 5.06(2H,q), 6.20(3H,vbr), 7.04(2H,m), 7.26(13H,m), 7.65(1H,d); m/Z 461 (M+H)+.

Provenance & Evidence