1-(4-Pyridyl)piperazine → HCID 18918575、化合物
反応式
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[N:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1>CO>[N:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:18][CH2:19][N:20]([C:2]3[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=3)[CH2:21][CH2:22]2)=[CH:13][CH:12]=1参加物
4
反応条件
- 温度
- 220 °C
実験手順
A mixture of 6-chloronicotinic acid (3.21 g) and 1-(4-pyridyl) piperazine (3.32 g) was heated to 220° C. for 3 minutes. The mixture was cooled and methanol (10 ml)was added. The resulting suspension was boiled for 10 minutes, cooled and filtered to give 6-[4-(4-pyridyl)piperazin-1-yljnicotinic acid (2.51 g) which was used without further purification.