反应详情

A mixture of 4-hydroxy-2-methylacetophenone (4.8 g), anhydrous potassium carbonate (5.3 g) and methyl bromoacetate (3.55 ml) in anhydrous acetone (100 ml) was stirred for 2 days. The mixture, after filtration and evaporation of the solvent, gave methyl 4-acetyl-3-methylphenoxyacetate, 6.6 g, as a crystalline solid: m.p. 49°-50° C.; NMR (d6DMSO) δ 7.84(1H,d), 6.83(2H,m), 4.87(2H,s), 3.71(3H,s), 2.50(3H,s), 2.45(3H,s).

1. filtrationThe mixture, after filtration and evaporation of the solvent