Potassium Carbonate → Methyl 4-acetyl-3-methylphenoxyacetate

HRID 1290508Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290508
[CH3:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]([CH3:11])=[O:10].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]([O:22][CH3:23])=[O:21]>CC(C)=O>[C:9]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:19][C:20]([O:22][CH3:23])=[O:21])=[CH:7][C:2]=1[CH3:1])(=[O:10])[CH3:11]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 701334-Hydroxy-2-methylacetophenone

Produkt 1

HCID 18918401Methyl 4-acetyl-3-methylphenoxyacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 4-hydroxy-2-methylacetophenone (4.8 g), anhydrous potassium carbonate (5.3 g) and methyl bromoacetate (3.55 ml) in anhydrous acetone (100 ml) was stirred for 2 days. The mixture, after filtration and evaporation of the solvent, gave methyl 4-acetyl-3-methylphenoxyacetate, 6.6 g, as a crystalline solid: m.p. 49°-50° C.; NMR (d6DMSO) δ 7.84(1H,d), 6.83(2H,m), 4.87(2H,s), 3.71(3H,s), 2.50(3H,s), 2.45(3H,s).

Aufarbeitung

  1. filtrationThe mixture, after filtration and evaporation of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-b1adf3ba6b7f42eb942bb31722f624df
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05750754

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