HCID 18918629, compound → HCID 131720652, compound

Participants

Reaction Steps

Following the method of Example 195ii), but staring from ethyl 5-[(4-pyridyl)piperazine-1-yl]pentanoate, dichydrochloride salt instead of ethyl 4-[(4-pyridyl)piperazin-1-yl]butyrate, dihydrochloride salt, the title compound was isolated after recrystallisation from wet ethanol, as an off-white crystalline solid in 59% overall yield: m.p. 294°-297° C. (dec); NMR (d6DMSO+CD3CO2D) δ 1.62(2H,m, 1.80(2H,m), 2.32(2H,t), 3.18(2H,m), 3.41(4H,m), 4.05(4H,m) 7.29(2H,d, 8.34(2H,d; m/Z 264 (M+H)+ ; calculated for C14H21N3O2. 2.0 HCl: C, 50.0%; H, 6.89%; N, 12.5%; found: C, 50.5% H, 7.2%; N, 12.2%.

Provenance & Evidence