Triethylamine → HCID 86638743, compound

Participants

Reaction Steps

A solution of methanesulphonyl chloride (0.85 ml) in dichloromethane (20 ml) was added dropwise to a stirred, ice-cooled solution of triethylamine (1.55 ml) and the product of step i) (2.64 g) in dichloromethane (50 ml). After stirring for 3 hours the reaction mixture was washed with water (3×) and brine, dried (PS paper) and evaporated in vacuo to yield N-benzyloxycarbonylpiperidin-4-ylethanol mesylate as a colourless paste (3.4 g) NMR (d6DMSO) δ 0.9-1.2(2H,m); 1.5-1.8(5H,m); 2.6-2.9(2H,m); 4.0(2H,d); 4.25(2H,t); 4.4(3H,s); 5.1(2H,s); 7.35(5H,m); m/e 342 (M+H)+.

Provenance & Evidence