Nitric Acid → 2,3-Dimethyl-5-nitroaniline
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[CH3:9].[N+:10]([O-])([OH:12])=[O:11]>S(=O)(=O)(O)O>[CH3:9][C:3]1[C:4]([CH3:8])=[CH:5][C:6]([N+:10]([O-:12])=[O:11])=[CH:7][C:2]=1[NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 12 °C
Procedure
363 g of 2,3-xylidine are run into 1.8 l of pure sulphuric acid while the temperature is kept at 40° C. To this solution, cooled to 12° C., a sulphonitric mixture (132 ml of nitric acid (d=1.52) and 180 ml of pure sulphuric acid) is added dropwise over 1 hour, the temperature not exceeding 15° C. After 15 minutes the mixture is poured onto 6 kg of ice with stirring.
Workup
- customis kept at 40° C
- customexceeding 15° C
Sources & evidence
- ORD record
- ord-c5457cac658944ec86ab2d44d8e9ab0d
- Source dataset
- uspto-grants-1998_05
- Patent number
- US05752982
Reaction notes
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