HCID 67641045, compound → HCID 18916198, compound

Participants

Reaction Steps

In a round bottom flask, there are introduced 300 mg (0.82 mmole) of the derivative obtained above in (c), 180 mg (4.5 mmoles) of soda and 10 ml of methanol. After 24 hours of reaction at reflux of the methanol, the mixture is evaporated and the remainder is taken up in water. The reaction mixture is neutralized to pH 5-6 by acetic acid. The resulting precipitate is filtered, washed with demineralized water and then dried for 48 hours at 80° C. 210 mg (78%) of the expected acid whose melting point is 170°-172° C. are obtained

Provenance & Evidence