HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → [2-(1-Methoxy-1-methylethyl)-6-fluorobenzoxazol-7-yl]carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | HCID 18916394 | HCID 18916394 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [2-(1-Methoxy-1-methylethyl)-6-fluorobenzoxazol-7-yl]carboxylic acid | HCID 18916446 | — |
Reaction Steps
An additional 2.1 grams of [2-(1-methoxy-1-methylethyl)-6-fluorobenzoxazol-7-yl]carboxylic acid of was prepared in the manner of Step B, Example 1, with 4.2 grams (17 mmole) of N-(3-chloro-4-fluorophenyl)-2-methoxy-2-methylpropionamide, 120 mL of tetrahydrofuran, 16 mL (40 mmole) of 2.5M n-butyllithium in hexanes, and 3.0 grams of solid carbon dioxide as reagents. The NMR spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05753595 |
| Source dataset | uspto-grants-1998_05 |
| ORD ID | ord-c065258c2bce43d6b73bc47d42764ba3 |
| Source note | uspto-grants-1998_05 |