Phenol → HCID 67717948, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, a stirred solution of 2.0 grams (51 mmole) of 60% sodium hydride (in mineral oil) in 25 mL of N,N-dimethylformamide is cooled in an ice bath, and a solution of 5.3 grams (56.3 mmoles) of phenol in 25 mL of N,N-dimethylformamide is added dropwise during a five minute period. To this is added a solution of 20.3 grams (51 mmole) of 3-(2,4-dichloro-6-fluorobenzoxazol-7-yl)-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione (as prepared in Example 24) in 25 mL of N,N-dimethylformamide. Upon completion of the addition the reaction mixture is allowed to warm to ambient temperature, where it stirs for about 18 hours. After this time the reaction mixture is concentrated under reduced pressure, yielding 3-(4-chloro-6-fluoro-2-phenoxybenzoxazol-7-yl]-1-methyl-6-trifluoromethyl-2,4-(1H,3H)pyrimidinedione.

Provenance & Evidence