HCID 86752572, compound → HCID 86752571, compound

Participants

Reaction Steps

To a solution of dihydro-3-bromo-1-pyrindine-6,6-diphosphonic acid tetraethylester (10 mmol) in THF (10 ml) cooled to -78° C. is added a solution of n-butyllithium (2.1 equiv) in hexane over 30 minutes. The reaction is kept at -78° C. for an additional 30 minutes. To this solution is added 2-iodoethanol trimethylsilyl (TMS) ether (2.5 equiv) and the reaction is allowed to warm to room temperature over 30 minutes. After standard aqueous work-up, dihydro-3-(2-hydroxyethanol, TMS ether)-1-pyrindine-6,6-diphosphonic acid tetraethyl ester is isolated and used in the subsequent reaction without purification.

Provenance & Evidence