4-Chlorobenzoyl chloride → HCID 18916107, compound

Participants

Reaction Steps

40.0 g (0.26 mol) of 4-piperidone hydrochloride (× H2O) and 38.6 g of potassium carbonate are suspended in 300 ml of tetrahydrofuran. 45.4 g of 4-chlorobenzoyl chloride are added thereto with stirring and the mixture is reacted for 2 hours at ambient temperature and refluxed for 2 hours. The reaction mixture is evaporated down in vacuo, the residue is neutralized with 2N hydrochloric acid and extracted with dichloromethane. 38 g of a viscous oil are obtained from the organic phase after removal of the extraction agent.

Provenance & Evidence