Cesium carbonate → HCID 18916999, compound

HRID 1290662Notes

Reaction equation

HRID 1290662 reaction equation
CS([C:5]1[N:10]=[C:9]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:8]([N+:19]([O-:21])=[O:20])=[C:7]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([N:31]([CH3:33])[CH3:32])=[O:30])[CH:24]=2)[N:6]=1)(=O)=O.[OH:34][C:35]1[CH:36]=[C:37]([CH:40]=[CH:41][C:42]=1[O:43][CH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:38]#[N:39].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH2:44]([O:43][C:42]1[CH:41]=[CH:40][C:37]([C:38]#[N:39])=[CH:36][C:35]=1[O:34][C:5]1[N:10]=[C:9]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:8]([N+:19]([O-:21])=[O:20])=[C:7]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([N:31]([CH3:33])[CH3:32])=[O:30])[CH:24]=2)[N:6]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 154534514-(Benzyloxy)-3-hydroxybenzonitrileHCID 18916753HCID 18916753, compound

Product 1

HCID 18916999HCID 18916999, compound

Procedure

In a similar manner, 2-methylsulfonyl-4-benzylamino-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine was treated with 3-hydroxy-4-benzyloxybenzonitrile in the presence of cesium carbonate to afford 2-(2-benzyloxy-5-cyanophenoxy)-4-benzylamino-5-nitro-6-(3-dimethylaminocarbonylphenoxy)pyrimidine, a compound of formula (P).

Sources & evidence

ORD record
ord-a77bcd249f02407498636f42041029d7
Source dataset
uspto-grants-1998_05
Patent number
US05753635

Reaction notes

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