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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1290715Generated: October 30, 2026

3-Hydroxy-2-nitropyridine → HCID 18795892, compound

https://huagongshe.com/reaction/1290715

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Hydroxy-2-nitropyridineHCID 27057—
ReactantEthyl 4-bromobutyrateHCID 76300—
ReactantSodium BicarbonateHCID 516892—
SolventDichloromethane methanolHCID 21226129—
ProductHCID 18795892HCID 1879589276%

Reaction Steps

This compound was prepared from ethyl 4-bromobutyrate 2 and 2-nitro-3-pyridinol (39) via the procedure of Step (A), supra. Following flash chromatography (silica gel; 1.5% methanol/methylene chloride eluant) a dilute sodium bicarbonate wash of an ether solution of the product was necessary to remove traces of starting phenol. The product (40) was obtained in 76% yield as a pale yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05753641
Source datasetuspto-grants-1998_05
ORD IDord-bbe69815921444259c45012e2412da42
Source noteuspto-grants-1998_05