Ethyl 4-bromobutyrate → Ethyl 4-(2-(11-carbomethoxyundecanoylamino)phenoxy)butyrate

HRID 1290719Notes

Reaction equation

HRID 1290719 reaction equation
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[OH:24])=[O:16])([O:3][CH3:4])=[O:2].Br[CH2:26][CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30]>>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[O:24][CH2:26][CH2:27][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])=[O:16])([O:3][CH3:4])=[O:2]

Participants

3

Reactant 2

HCID 76300Ethyl 4-bromobutyrateHCID 18795789N-(11-Carbomethoxyundecanoyl)-2-hydroxyaniline

Product 1

HCID 18796179Ethyl 4-(2-(11-carbomethoxyundecanoylamino)phenoxy)butyrate

Procedure

When (44) and 4-bromobutyronitrile are reacted under the conditions of step (A), above, (45) is obtained as a waxy solid. Conversely, reacting (44) with ethyl 4-bromobutyrate as in step (A) yields (8).

Sources & evidence

ORD record
ord-75065ec92d484d2892ccdc7ec9d672be
Source dataset
uspto-grants-1998_05
Patent number
US05753641

Reaction notes

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