Ethyl 3-anilino-2-cyano-3-methylsulfanylprop-2-enoate → Ethyl 3-[4-(p-fluorobenzyl)-2-morpholinylmethylamino]-3-phenylamino-2-cyanoacrylate

HRID 1290724Notes

Reaction equation

HRID 1290724 reaction equation
[C:1]1([NH:7][C:8](SC)=[C:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:19][CH2:20][CH:21]1[O:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[CH2:22]1>>[F:34][C:31]1[CH:32]=[CH:33][C:28]([CH2:27][N:23]2[CH2:24][CH2:25][O:26][CH:21]([CH2:20][NH:19][C:8]([NH:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[C:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:22]2)=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 4200299Ethyl 3-anilino-2-cyano-3-methylsulfanylprop-2-enoateHCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

Product 1

HCID 70110258Ethyl 3-[4-(p-fluorobenzyl)-2-morpholinylmethylamino]-3-phenylamino-2-cyanoacrylateYield 66%

Procedure

This compound was synthesized from ethyl 3-phenylamino-3-methylthio-2-cyanoacrylate and 2-aminomethyl-4-(p-fluorobenzyl)morpholine according to the same procedure as in Example 8. Yield=66%.

Sources & evidence

ORD record
ord-048b04db5cde4fe5972b5a47ee8ec1e1
Source dataset
uspto-grants-1998_05
Patent number
US05753654

Reaction notes

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