2-Aminomethyl-4-(4-fluorobenzyl)morpholine → HCID 70109414, compound

HRID 1290725Notes

Reaction equation

HRID 1290725 reaction equation
[CH2:1]([NH:5][C:6](SC)=[C:7]([C:13]#[N:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]([CH3:4])[CH3:3].[NH2:17][CH2:18][CH:19]1[O:24][CH2:23][CH2:22][N:21]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH2:20]1>>[F:32][C:29]1[CH:30]=[CH:31][C:26]([CH2:25][N:21]2[CH2:22][CH2:23][O:24][CH:19]([CH2:18][NH:17][C:6]([NH:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[C:7]([C:13]#[N:14])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:20]2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholineHCID 86752574HCID 86752574, compound

Product 1

HCID 70109414HCID 70109414, compoundYield 22%

Procedure

This compound was synthesized as a yellow oily substance from ethyl 3-isobutylamino-3-methylthio-2-cyanoacrylate and 2-aminomethyl-4-(p-fluorobenzyl)morpholine according to the same procedure as in Example 8. Yield=22%.

Sources & evidence

ORD record
ord-9f05ec65a82844a0b5665e331bd3b0fb
Source dataset
uspto-grants-1998_05
Patent number
US05753654

Reaction notes

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