2-Aminomethyl-4-(4-fluorobenzyl)morpholine → HCID 70108174, compound

HRID 1290726Notes

Reaction equation

HRID 1290726 reaction equation
[CH:1]1([NH:7][C:8](SC)=[C:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:19][CH2:20][CH:21]1[O:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[CH2:22]1>>[CH:1]1([NH:7][C:8]([NH:19][CH2:20][CH:21]2[O:26][CH2:25][CH2:24][N:23]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=3)[CH2:22]2)=[C:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholineHCID 70109935HCID 70109935, compound

Product 1

HCID 70108174HCID 70108174, compoundYield 10%

Procedure

This compound was synthesized as a yellow oily substance from ethyl 3-cyclohexylamino-3-methylthio-2-cyanoacrylate and 2-aminomethyl-4-(p-fluorobenzyl)morpholine according to the same procedure as in Example 8. Yield=10%.

Sources & evidence

ORD record
ord-3ddb35f2daab45ed8781d100c8a97497
Source dataset
uspto-grants-1998_05
Patent number
US05753654

Reaction notes

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