反应详情

温度

80 °C

To ethyl 3-benzylamino-3-methylthio-2-cyanoacrylate (1.50 g, 5.43 mmol) and 1-(p-fluorobenzyl)piperazine (2.11 g, 10.9 mmol) was added acetonitrile (1 ml) and the mixture was heated under reflux at 80° C. for 2 hours. The reaction product was purified by silica gel column chromatography to give the title compound as a brown oily substance (0.48 g) from the fraction from hexane-ethyl acetate (1/1). Yield=21%.

1. temperaturethe mixture was heated
2. customThe reaction product was purified by silica gel column chromatography